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What they found: 4,192 human genes change expression by 2 in response to GHK-Cu (31.2 % of the human genome) Of these 2,296 genes up-regulated , 1,896 down-regulated Pattern of changes: a rejuvenating signature, genes typically associated with ageing are down-regulated, regenerative genes up-regulated DNA repair , strong up-regulation of genes in BER, HR, NER pathways Mitochondrial biogenesis , increase in the number of mitochondria in cells Anti-apoptotic signal , protection against cell death Down-regulation of cancer signals , some oncogenes decreased Why it matters: This is the strongest evidence for the pleiotropic nature of GHK-Cu
Acknowledgements The authors received no funding for the publication of this work
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LeMaistre Distinguished Chair in Thoracic Oncology, Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX Professor, Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX Research Interests An author of more than 260 peer-reviewed publications, Dr
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