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Addressing this accumulated damage requires regenerative processes the peptide appears to stimulate

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Another study also reported the anticatabolic and cartilage protective potential in rat chondrocytes [178]

An in-vitro study found that berberine protected NSC34 cells from H 2 O 2 -induced cytotoxicity by reducing ROS production, restoring glutathione, and superoxide dismutase activity, and activating the production of antioxidant proteins nuclear factor erythroid 2-related factor-2 (Nrf2) and HO-1 (Hsu et al., 2012