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[4] Clinical assessment should focus on identifying the cause of elevated levels rather than assuming toxicity from supplementation alone

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The glutathione molecule plays a crucial role in maintaining our bodies finely tuned balance, acting as a cellular guardian to protect us from the constant onslaught of oxidative stress and toxic compounds (Sies, 1999)

The expression of the immunoproteasome 5i, which is important for the degradation of oxidized proteins under stressful conditions, was decreased in ibuprofen treated male livers relative to controls whereas it was increased in female mice livers in ibuprofen treated group