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What the Evidence Actually Shows This is the section to read slowly, because it is where the honesty lives

Most patients begin noticing shifts in symptoms reduced flare frequency, less urgency, improved tolerance within 48 weeks, with continued improvement over 36 months

The risk, however, lies less with the molecule itself than with the quality of the preparation and the conditions of administration: a cluster of seven cases of endotoxin poisoning was described after infusions prepared from contaminated raw material not intended for intravenous use (Johnstone et al., Epidemiology and Infection 2018, PMID 29673413)

The serotonin in the intestinal mucosa stimulates the production of proinflammatory mediators by immune cells