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The authors concluded: The exposome accelerates brain aging in health and disease. That study measured country-level factors including air quality, temperature, greenspace, socioeconomic inequality

Influences of aflatoxin B1 on reactive oxygen species generation and chemotaxis of human polymorphonuclear leukocytes

To study the permeability of nanoparticles in vitro BBB models, which conform to the 3R principles with the minimalization the number of animal experiments, are widely used either in static [34] or in dynamic conditions by employing lab-on-a-chip systems [35]

In conclusion, using disrupted molecular and behavioral circadian rhythms as a read-out for methyl metabolism deficiency, we show that the methyl cycle is highly sensitive to exogenous variations of its metabolites, and that excess SAM beyond endogenous levels, rather than promoting methylation, has negative consequences due to its catabolism to MTA and adenine by the methionine salvage pathway