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Similarly, CUR alters the pharmacokinetics of blood pressure medications, potentially compromising their efficacy or safety (80)

[7] [9] Patients with a history of oxalate nephrolithiasis (kidney stones) or hyperoxaluria should avoid high-dose vitamin C administration, as ascorbic acid is metabolized to oxalate, which may precipitate stone formation or exacerbate renal impairment

Hair loss along the hairline is common (Figure 3C)

Specifically, one double-blind trial in 140 patients with chronic schizophrenia, described by the Cochrane Collaboration as a high quality trial that measured clinically-useful outcomes (Positive and Negative Syndrome Scale [PANSS] and Clinical Global Impression [CGI]) over a longer period of time [145], compared adjunctive NAC versus placebo [146]