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127, 128, 129 In addition, Ang IV was reported to promote the release of vasodilating prostaglandins

SAM is additionally required for phosphatidylcholine synthesis, which is abundant in neuronal membranes and is crucial for synaptogenesis and neurite outgrowth ( Vitamin B12 is a cofactor for the enzyme methylmalonyl-CoA mutase, which converts methylmalonyl-CoA to succinyl-CoA, a crucial step in fatty acid metabolism (73)

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Interest continues in its neuromodulatory and circadian-regulating properties in preclinical and clinical research contexts