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Therapy with a GLP-1 RA or sodium-glucose cotransporter 2 inhibitor (SGLT2 inhibitor) that has proven CV benefit is recommended for initial therapy, with or without metformin based on glycemic needs, in patients with indicators of high-risk or established CV disease

Established benefits of B12 therapy: Treatment of documented deficiency: Intramuscular hydroxocobalamin is the standard NHS treatment for pernicious anaemia and other causes of B12 deficiency, effectively reversing haematological and neurological complications

This size is common among adults who take medium-range insulin doses each day

Doctors may advise muscle B12 injections for severe vitamin B12 deficiency caused by an insufficient intrinsic factor (pernicious anemia)