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In addition to the conditions mentioned above, several risk factors increase the likelihood of B12 deficiency: Smoking Alcohol abuse Endocrine-related autoimmune disorders (such as diabetes or thyroid disorders) Gastrointestinal disorders like Crohns disease History of gastric bypass surgery or other stomach-altering surgeries Optimize Your Health

Conversely, H3K4me2, an activating mark associated with gene expression, decreases by 65%, reducing expression of genes essential for sperm development (92)

Tan HC, Dampil OA, Marquez MM