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10.1007/s00018-016-2194-1 16 CaoY.LiY.HeC.YanF.LiJ.-R.XuH.-Z.et al (2021)

For researchers focused primarily on metabolic markers, the 4mg to 8mg range appears to provide strong metabolic benefit with a favorable side effect profile

This herb should never be used during pregnancy, as it has been associated with dangerous side effects like high blood pressure, heart attacks, and seizures