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MOTS-C is a mitochondria-derived peptide that activates AMPK, the master metabolic switch, and directly improves mitochondrial function

Vila M, Laguna A, Carballo-Carbajal I (2019) Intracellular crowding by age-dependent neuromelanin accumulation disrupts neuronal proteostasis and triggers Parkinson disease pathology

10.1016/S1054-3589(08)61084-4 Adv

Second, HA enhances oxidative stressparticularly lipid peroxidationand promotes intracellular iron accumulation in granulosa cells, thereby activating ferroptosis (33)