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Description

Beyond proteasomal targeting, non-canonical ubiquitin modifications, including K63-linked polyubiquitination, regulate signaling, endocytosis, kinase activity, and DNA damage responses, while mono- and multi-ubiquitination influence chromatin dynamics, DNA repair, and subcellular localization (Fig

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The effectiveness of the components is confirmed by clinical studies

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doi:10.1016/S0140-6736(21)01751-7 DAscanio AM, Mullally JA, Frishman WH

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