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10.1016/s1090-7807(02)00014-19 J

Physical enhancement methods including iontophoresis, microneedling, and ultrasound also significantly increase GHK-Cu delivery, with microneedling pre-treatment increasing peptide penetration by approximately 10-fold compared to intact skin application, effects similar to those achieved with other topical peptide formulations optimized for transdermal delivery

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It is worth mentioning that 80% of cases that worsen and affect the abnormal condition of the skin are related to an improper lifestyle, which includes many factors such as stress, UV rays, lack of sleep, improper diet, smog, smoking, or alcohol consumption