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And then you get into antagonistic pleiotropy

This disrupts axonal transport, destabilizes cytoskeletal architecture, and contributes to neuronal death (Duggal and Mehan, 2019)

doi: 10.1093/humupd/dmh032 132 CaratyASmithJTLometDBen SadSMorrisseyACognieJet al

Summary Keywords amodiaquine, quinoneimine, cytotoxicity, endoplasmic reticulum stress, human glutathione S -transferases P1 Citation Zhang Y, den Braver-Sewradj SP, den Braver MW, Hiemstra S, Vermeulen NPE, van de Water B, Commandeur JNM and Vos JC (2018) Glutathione S -Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells