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Long-term use of some supplements, particularly those with high doses of specific nutrients, may also elevate risks of chronic conditions like diabetes or cardiovascular issues

Cautious use of parenteral cyanocobalamin is also recommended in patients with renal impairment, including premature neonates, because of the possibility of greater aluminum accumulation, which may cause central nervous system and bone toxicity

The kidneys may retain more sodium and water

Any discrepancy between the two investigators on NOS scores of the enrolled studies was resolved by discussion or consultation with a third investigator