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Depending on the topic under review, the committee evaluates scientific, technical, and clinical evidence and discusses factors such as safety, clinical need, and the availability of therapeutic alternatives

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Currently, treatments based on copper metabolism in cardiovascular disease can encompass a wide range of options, including copper chelating agents [such as triethylenetetramine (TETA), tetrathiomolybdate (TTM) and disodium ethylene diamine tetraacetic acid (EDTA)], small-molecule inhibitors of copper chaperone proteins (such as DCAL50), copper ion carriers and natural antidote agents (Table II)

For injury treatment, continuous use through complete healing (up to 12 weeks) is reasonable, followed by a break