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Additionally, glutathione may interact with chemotherapeutic agents

(5) Adverse Effects and Contraindications: The most notable adverse effect is increased blood pressure

In fact, worsening asthma control and exacerbations are consistently linked to lower lung GSH levels and higher oxidative potential (35, 36)

They add that as immunotherapies are being more commonly utilized as first- and second-line treatments, immunotoxicity and autoimmunity are emerging as the Achilles heel of immunotherapy. In their Cancer Immunology Research paper, Bluestone and colleagues briefly discuss immunotherapeutic strategies that can potentially prevent irAEs, such as targeting intratumoral T cells directly, using bispecific antibodies to enhance localized targeting of tumor, and using engineered cell therapies to fine-tune immune cell responses