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People with CFS may be better supported by a customized assessment by an experienced clinician that may also include methyl folate and methyl vitamin B12

Reconstitution Considerations: Due to N-terminal lipidation , complete dissolution may require gentle vortexing or brief sonication

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Exposure to stress resulted in diminished hippocampal brain-derived neurotrophic factor (BDNF) expression in the CA3 region of neurons, a decrease in exploratory behavior, an increase in fecal output, and heightened levels of neuronal nitric-oxide synthase (nNOS), all of which are indicative of neural impairment (72)