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Genomic studies and animal models have indicated that Se intake influences the expression of selenoprotein genes and pathways key to colorectal carcinogenesis such as the antioxidant response, immune and inflammatory pathways (including NF-kB and Nrf 2 signaling), the Wnt signaling pathway, protein synthesis pathway (Ye et al., 2021)

Distinct role of ERp57 and ERdj5 as a disulfide isomerase and reductase during ER protein folding

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In cell and animal models, this mechanism has been linked to: Because of its role in the NAD salvage pathway, 5Amino1MQ is increasingly studied alongside other longevity molecules like NMN, NR, and resveratrol, but with a more direct effect on the gene associated with metabolic slowdown