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Description

Steward Alexander 313 ) is an incurable genetic astrocytopathy caused by sporadic mutations in the GFAP gene

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Owing to hypermethylation of the promoter, RIPK3 is silenced in primary tumours but significantly upregulated in recurrent lesions, with an enhanced dependence on cysteine metabolism, suggesting that targeting RIPK3 may inhibit tumour recurrence [56]

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