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low-stress baselines, and in sleep-deprived states Bottom line: PE-22-28 looks promising and well-tolerated in early research, but without human trials, the safest posture is conservative: short, well-spaced research cycles, careful observation, and avoidance of stacking with heavy CNS-active agents unless a protocol explicitly tests that interaction

Therefore, future research should prioritize: (i) establishing rigorously validated digital biomarkers to enable objective and real-time monitoring of disease status, such as indicators of autonomic dysfunction linked to PEM

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Implications of gastrointestinal manifestations of COVID-19