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Recent studies from our laboratory (Yamamoto et al., 2010) have shown that picomolar concentrations of the AngIV analog, Norleual (Nle-Tyr-Leu--(CH 2 NH 2 ) 3-4 -His-Pro-Phe), are capable of potently inhibiting the HGF/Met system and bind directly to the hinge region of HGF blocking its dimerization (Kawas et al., 2011)

Reduced risks of cancer, cardiovascular complications, diabetes and asthma have been shown to be a result of using this as a dietary supplement (6)