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Description

Inhibition of GLS-1 starting at 1 M of CB-839 was enough to reduce the mean glutathione concentration by at least 51% in both the HG-3 and MEC-1 cell lines compared to the controls

Its main characteristics are as follows (1): During the process of cell death, a large amount of iron accumulates, and lipid peroxidation occurs, activating signaling pathways such as oxidative stress ( Table 1 Comparison of cell death pathways