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Causes : Theoretically any drug may trigger DRESS syndrome, but the medications most commonly implicated are drugs that are used to treat seizures (e.g., carbamazepine, phenytoin, phenobarbital), gout (e.g., allopurinol), antibiotics (e.g., especially penicillin), and many anti-viral medications (e.g., boceprevir, telaprevir, abacavir, nevirapine) The exact mechanism of the hypersensitivity to drugs causing this condition is not clearly understood

As for Japanese patients, approximately half of them showed a history of influenza-like infection within a period of one month preceding DRESS.12 The specific mortality rate for DRESS varies from 3% to 20%, representing a dermatological emergency.1517 Approximately 94% of the patients require hospitalization, with an estimated economic cost to the American healthcare system of at least US$17,000 per patient.16,18 In the study by Wolfson et al