10.1080/02652030600838407 3 BiffigerK.BartschS.MontagD.AguzziA.SchachnerM.BartschU
It is made from three amino acids: cysteine glycine glutamate These amino acids combine to form a molecule that protects cells from oxidative stress
Khavinson, V., Ilina, A., Kraskovskaya, N., Linkova, N., Kolchina, N., Mironova, E., Erofeev, A., & Petukhov, M
Microbial-associated molecular patterns, such as LPS, translocate to the liver through the damaged gut barrier, are recognized by TLR4 on the surface of Kupffer cells, activate the downstream MyD88/NF-B signaling pathway, drive the massive release of pro-inflammatory cytokines (such as TNF-, IL-1, IL-6), and thereby initiate and maintain the inflammatory state of the liver, which is crucial in the pathogenesis of ALD and NASH