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This was confirmed to me by my business partner and genius biochemist Nick Andrews, who had the following to say: Chronic administration has been tested and shown to not generate toxic or negative effects while generating the positive effects observed in adipose tissue as well as muscle tissue. My best guess is that this is supported by what has been seen in animal and cell models thus far: 5-amino-1MQ shows in vivo therapeutic efficacy in murine models of DIO (20 mg/kg/d sc.), muscle injury (5 or 10 mg/kg bid

Although you cannot measure collagen levels in your body, decreasing collagen manifests as joint pain and stiffness

Clinical Indications for Higher IV Dosages For very severe cases, like serious neurological problems, higher doses of IV vitamin B12 might be needed

The increased oxidative damage leads to apoptosis