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UGT1A8, UGT1A9, UGT1A10, and UGT2B7 are involved in the metabolism of MPA to MPAG

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Intravenous administration in healthy adults showed excellent tolerability, with no adverse effects on cardiac, hepatic, renal, or thyroid biomarkers at doses up to 20 mg

These experiments were performed by titrating fluorescently-labeled TyrBm with increasing concentrations of KA, HQ or L-tyrosine as the unlabeled ligands