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The pituitary gland releases GH in pulses, and that release is gated by two independent controls: a go signal from GHRH and a separate go signal from the ghrelin/GH-secretagogue receptor

Amidated peptides have been observed to exhibit reduced sensitivity to proteolytic degradation and, in some cases, increased receptor binding affinity relative to their acid-form counterparts (2)

Of course, when copper concentrations exceed the physiological range, mitophagy is involved, aggravating mitochondrial membrane damage and functional impairments [139]