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However, regardless of their definite positive effects, therapeutic applications of natural neurotrophins like NGF and BDNF, for treatment of neurodegenerative diseases, are limited due to their inability to cross blood brain barrier and also susceptibility to degradation by peripheral peptidases (Tomioka et al., 2014)

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2 FcRn-Mediated Control of IgG and Albumin Homeostasis FcRn has a heterodimeric composition resembling a major histocompatibility complex (MHC) I molecule, with a unique transmembrane heavy chain (HC) that is paired with the common soluble 2-microglobulin (2m) [19]