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There is also a correlation between IL-6 levels, disease severity and ocular surface parameters [68]

To overcome challenges such as biosafety, off-target effects, and clinical translatability, strategies successfully explored in other diseases, such as biodegradable or organicinorganic hybrid nanozymes, pH-responsive targeting designs, erythrocyte membrane coatings, and ROS-responsive carriers, may be adapted to enhance tissue specificity and safety in IMID treatment

However, the existing evidence that supports the neuroprotective qualities of curcumin is sufficient to justify its use in future research on autism and related conditions [103]

The enzymatic protective mechanisms responsible for reacting with ROS include superoxide dismutase (SOD), catalase, peroxiredoxins, glutathione peroxidase, and glutathione reductase, among others