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Among these, non-covalent DPP1 inhibitors have attracted considerable attention due to their unique pharmacokinetic characteristics and potential safety advantages ( 10 Comparison of DPP1 inhibitors with other treatment strategies 10.1 Comparison with direct NSP inhibitors Direct NSP inhibitors, particularly NE inhibitors such as AZD9668, have undergone Phase II studies in bronchiectasis patients but failed to significantly improve patient clinical symptoms (Stockley et al., 2013)