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274 A phase 2 study testing semaglutide enrolled 320 patients with MASH and fibrosis and randomized them to 0.1, 0.2, or 0.4 mg semaglutide group or the placebo group

doi: 10.1080/15548627.2015.1038016 23 HuangX.YingJ.YangD.FangP.WangX.ZhouB.et al

Chronic oxidative stress is linked to a wide range of diseases, including: Cardiovascular disease : ROS damage endothelial cells lining blood vessels, promoting atherosclerosis and hypertension.[9] Neurodegenerative disorders : Oxidative damage to neurons is a key driver in conditions like Alzheimers, Parkinsons and ALS.[10] Diabetes and insulin resistance : Oxidative stress impairs insulin signaling and worsens glycemic control.[10] Cancer : DNA mutations caused by free radical damage may initiate or accelerate tumor development.[11] Autoimmune conditions : Oxidative stress can trigger inflammatory pathways, contributing to immune dysregulation.[9] Even outside of these conditions, oxidative stress contributes to fatigue, slower recovery, immune suppression and premature aging at the cellular level

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