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[PubMed] [Google Scholar] 29.Kolovrat M, Gojkovic S, Krezic I, Malekinusic D, Vrdoljak B, Kovac KK, et al

Mechanistically, A42 disrupts LONP1 function through dual pathways: (1) by inhibiting METTL3-mediated LONP1 mRNA m 6 A to negatively regulate LONP1 expression, and (2) by directly binding to LONP1, inducing conformational changes in the protease complex, thereby markedly inhibiting its oligomerization process and substrate hydrolytic activity