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Peer review Peer review information Nature Communications thanks Gawain McColl, Jie Zhao and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

So, did a quick query on Google Gemini Pro to get a quick overview (not wanting to that long document until I knew a little more): FOXO4-DRI Current scientific consensus as of 2026 characterizes FOXO4-DRI (D-Retro-Inverso) as a potent experimental senolytic peptide with robust preclinical evidence but limited clinical validation

Increased SOD1 activity results in the creation of elevated levels of H 2 O 2 that should be effectively removed by other enzymes, such as CAT, GPx, and thioredoxin peroxidase

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