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It is released from the extracellular matrix during tissue injury specifically cleaved from SPARC (Secreted Protein Acidic and Rich in Cysteine) and the alpha 2(I) chain of type I collagen.[2] Age-related decline: Plasma concentration declines from approximately 200 ng/mL (10 M) at age 20 to roughly 80 ng/mL by age 60

Its safety profile in early human trials appears good, though long-term data are limited

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In this era of precision and personalized medicine there is an increasing need to develop a POCT with molecular genetic testing that produces a risk assessment based on a comprehensive profile for targeted therapy