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It is not recommended for individuals with severe liver, kidney, or heart disease without prior medical clearance

It is the point where the medication becomes effective for the patient

[DOI] [PubMed] [Google Scholar] 674

Systemic vaginal delivery of estradiol and progesterone is advocated as higher bioavailability than oral/topical/patch routes, aiming to suppress elevated FSH and improve cognition, sleep, mood, gut/gallbladder function, and sexual function