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Large-scale lactylation histology studies confirm the presence of Kla in a large number of non-histone proteins, including NCL, YY1, and HMGB1, and these modifications regulate transcription, signal transduction, and ribosome assembly by altering protein conformation, charge distribution, and molecular interactions, thereby revealing the broad regulatory potential of lactate as a signaling molecule [78,79,80]

In the Nutrients paper, reference is made to a number of studies of healthy individuals, wherein glutathione stores improved following whey protein supplementation, since whey has a higher cysteine content

doi: 10.1093/eurheartj/ehx352 204

cDNA was synthesized from the total RNA in a 20 L reaction by cDNA Synthesis SuperMix kit (AT311-03, TransGen Biotech)