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Kreteks are largely banned or strictly regulated as cigarettes in countries like the US, where they are often classified as flavored cigarettes

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105 applied high-resolution imaging, namely quantitative computed tomographic (QCT), to the radiological analysis of airway morphology, reflecting airway remodeling in patients with asthma or COPD by OCT parameters

Nonetheless, neuroimaging studies have documented smoking-related volumetric increases in the caudate and putamen [17, 86], positive correlations between putamen volume and lifetime nicotine/tobacco exposure [107], and positive correlations between greater striatal volume and more intense cue-induced tobacco craving [108]