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(1) uninfected macrophages express anti-inflammatory responses, including polarization of CD206 + M2 macrophages and increased expression of IL10, whereas (2) infected macrophages show inflammatory responses, including differentiation to M1 macrophages and increased expression of iNOS, TNF-, and IL6

By contrast, cigarette smoking carries substantially higher mortality risks, with studies showing mortality rates among smokers approximately three times higher than among people who have never smoked

We are committed to making sure that the tobacco industry plays its part