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Nicotine, the highly addictive substance found in most tobacco products and in many e-cigarettes, can cause several cardiovascular problems, including: Hardening and narrowing of arteries Increased blood pressure Increased heart rate After standardizing data from the cohort of studies, the authors identified an increased risk of specific heart and blood vessel conditions associated with each type of tobacco product: Use of cigars increased the risk of: Smokeless tobacco led to a higher risk of: Pipe use was associated with a higher risk of: Heart failure Statistical analysis demonstrated that cigarette smoking was consistently associated with higher risk for all the heart health outcomes studied

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