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Sandoval and DAlessio (2015)
They can not only serve as representative readings of the functional output of microorganisms, but also may act as potential remote immune regulators in the intestinal-articular axis by affecting the energy metabolism and barrier balance of the intestinal epithelium, and regulating the activation threshold and cytokine network of immune cells (Kasubuchi et al., 2015)
15 DVL proteins located in the cytoplasm are pivotal in the transduction of WNT signalling from the receptor level to the intracellular compartment and contain three highly conserved domains: the DIX domain at the N-terminal side (the site interacts with AXIN), the PZD domain in the central part, and the DEP domain at the C-terminal side
It also partially activates the expression of GSH, GPX4, and SLC7A11, and inhibits the expression of ROS and IL-18 [156]
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