MetS is a complex group of abnormal metabolic symptoms that are closely associated with cardiovascular disease (CVD), including a state comprising abnormal lipid metabolism, hypertriglyceridemia, lowered high-density lipoprotein (HDL) cholesterol, increased arterial blood pressure, and impaired glucose tolerance [4, 5], which progressively causes hypertension, central obesity, insulin resistance (IR), dyslipidemia, and dysregulation of glucose homeostasis, increasing the risk of individuals developing type 2 diabetes mellitus (T2DM) and CVD [6, 7]
Usually cells (including melanocytes) have distinct overlapping mechanisms for coping with ROS/antioxidant imbalance from multiple sources to prevent cellular damage 29,30,31,32,33
Stewart DJ, Behrens C, Swisher SG , Roth JA, Heymach JV, Wistuba II
Within that ecosystem, the DoDs Small Business Innovation Research program alone allocates more than $2 billion annually distributed across more than a dozen components, each with its own technology priorities and active solicitations
