The cause of the plague, however, is an insurance industry which adopted a standard policy which is inadequate to deal with the problems of asbestosis. BY this time, as might be expected, a number of other declaratory-judgment actions had been filed in other jurisdictions by insurers or defendant manufacturers who, depending on the particular circumstances and, of course, on the extent of their financial liabilitywere either for or against the exposure theory
However, lingering symptoms can still occur for several months
Specifically, cigarette smoke activates damage-associated molecular patterns (DAMP) and pathogen-associated molecular patterns (PAMPS) in lung epithelial cells and alveolar macrophages, which activate Tolllike receptors (TLRs) and NODlike receptors (NLRs)
Similarly, mouse lung exposure to carbon black nanoparticles causes the activation of the NLRP3 inflammasome, which leads to lung injury and emphysema [73]