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Long R3 IGF-1 bioactivity and reduced IGFBP affinity Bach et al

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Nitric oxide (NO) pathway involvement, consistent with earlier research showing BPC 157's regulatory effects on vascular tone and tissue healing

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In OA and other chronic degenerative disorders, cells and tissues also undergo shifts in energy metabolism and biosynthetic pathways to adapt to pathological microenvironments characterized by hypoxia, inflammation, mechanical stress, and nutrient limitation ( 3.1 Lipid metabolic reprogramming 3.1.1 PUFAs and lipid peroxidation Lipid peroxidation is the central event in ferroptosis

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