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Nicotine reduces flow-mediated dilation (FMD) 11 and increases arterial stiffness in healthy volunteers, even in the absence of other tobacco constituents

However, many people who use nicotine are surprised to learn that it can also have a toxic and dangerous effect on your heart and blood vessels

Keaton's career began on stage, acting in the ensemble of the original Broadway production of the musical Hair (1968) and the romantic interest in Woody Allen's comic play, Play It Again, Sam (1969), the latter of which earned her a nomination for a Tony Award for Best Featured Actress in a Play

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