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It was shown that increased HO-1-derived CO production has a vascular protective effect on T1DM, reduces endothelial cell fragmentation, and decreases ICAM-1, VCAM-1 expression, and Caspase-3 activity [122]

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Studies have described that flavonols and their derivatives are likely the substrate for GSTLs, which tightly bind to these small molecules ( Arabidopsis and wheat Lambda class GSTs ( AtGSTL1, TaGSTL1 , and TaGSTL3) have been identified to be localized in cytosol, whereas others ( AtGSTL2 and TaGSTL2) are chloroplast localized (Theodoulou et al., 2003)

W., Massie, A., Smolders, I., Methner, A., Pergande, M., Smith, S