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It is really cool to discover a selective pathway for beige fat, a new cell typeand even more exciting that this is conserved in humans. To better understand what makes beige fat unique, researchers analyzed activated beige fat and uncovered a molecule directly linked to thermogenesis in these cells: CHRNA2 (for cholinergic receptor nicotinic alpha 2), a type of receptor that is best known for regulating nicotine dependence in brain cells

Regulatory implications The introduction of nicotinamide as a nicotine replacement in e-cigarette and smokeless products represents a significant regulatory challenge for the FDA