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This animation shows how the heat from tobacco combustion causes molecules to fragment into unstable arrangements, which recombine to form carcinogenic compounds of polycyclic aromatic hydrocarbons, or PAH's

So how does this translate to nicotine-containing products

What happens if I break someone's water pipe or hand pipe

Nicotine can also promote endothelial dysfunction, inhibit cellular apoptosis and enhance angiogenesis, thereby raising concerns about its possible role in the pathophysiology of atherosclerosis and even cancer development.92,93 Interestingly, in another experiment, rats exposed to electronic cigarette refill liquid had better metabolic profiles, with decreased total cholesterol, low-density lipoprotein cholesterol and low-density lipoprotein:high-density lipoprotein ratio