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[97] The effects of CO, such as the widespread binding of Hb and the reduced arterial O2 blood saturation, the insufficiency of respiratory enzymes, in combination with the binding of myoglobin and the effects of CO on aerobic metabolism, result in dysfunction of the O2 production, transportation, and delivery system, especially during exercise

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And while manufacturers point out that ingredients like glycerin or propylene glycol are generally recognized as safe by the FDA, that designation only applies when the ingredients are eaten -- not when theyre inhaled