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Slices were stimulated with a vehicle, Nle-AngIV, or Dihexa for 2 days

Gamma-glutamylcysteine regulates macrophage polarization, modulates the trafficking of CD36 and GLUT4 , induces glutathione synthesis, improves metabolic dysfunction, reduces lipid deposition, ameliorates glucose homeostasis, inhibits apoptosis ( Apoptosis ), stabilizes mitochondria, suppresses lipid peroxidation, iron accumulation and ferroptosis ( Ferroptosis ), reduces ds-HMGB1 levels, reverses mechanical hyperalgesia, and alleviates hepatic lipid droplet formation

This should be considered in individuals with diabetes or those at risk of hypoglycemia